To evaluate the safety, an implantation study was conducted in a subcutaneous mouse model. Very little gas was produced as the clip dissolved and there was no inflammation of the surrounding tissues after 1 to 12 weeks. These results suggest that the clip is associated with very few adverse effects.
Blood testing revealed that levels of magnesium and other substances in the blood were in the normal range after 12 weeks. The volume of the implanted clip was reduced by almost half after 12 weeks. Therefore, the clip is likely to dissolve and exit the body within 1 year.
To evaluate its functionality, it was tested in a rat model in which the biliary duct, portal vein, hepatic artery, and hepatic vein were occluded with the clip and a partial liver was removed. The rat had no problems during a monitoring period of 8 weeks, suggesting that the clip functioned properly.
Micro CT scanning of the mouse and rat revealed that the quality of images was not degraded and organs can be observed. Professor MUKAI Toshiji Department of Mechanical Engineering, Graduate School of Engineering , who was involved in developing the clip, expressed his hopes: "We will conduct further in vivo studies and a clinical study within 2 to 3 years.
Kobe University works toward the development of new medical devices. We will continue to promote collaboration between the Graduate Schools of Medicine and Engineering. The researchers evaluated the safety of the clip by conducting an implantation study in a subcutaneous mouse model. They found that very little gas was produced as the clip dissolved and there was no inflammation of the surrounding tissues after one to 12 weeks.
These results suggest that the clip is associated with very few adverse effects. In addition, blood testing showed that levels of magnesium and other substances in the blood were in the normal range after 12 weeks.
The volume of the implanted clip was reduced by almost half after 12 weeks. Hence, the clip is likely to dissolve and exit the body within one year, says the research team. To evaluate the clip's functionality, the researchers used it in a rat model in which the biliary duct, portal vein, hepatic artery, and hepatic vein were occluded with the clip and a partial liver was removed. The rat experienced no problems during a monitoring period of eight weeks, suggesting that the clip functioned properly.
Of note, micro CT scanning of the mouse and rat revealed that the quality of images was not degraded and organs can be observed.
Kobe University works toward the development of new medical devices. We will continue to promote collaboration between the Graduate Schools of Medicine and Engineering. Imaging , MRI , computed tomography , surgical clip , dissolvable. No comment Please login to leave a comment Citation, DOI and case data.
Kecler-Pietrzyk, A. Displaced cholecystectomy clips. Case study, Radiopaedia. Full screen case. Case with hidden diagnosis. Full screen case with hidden diagnosis.
Presentation Right upper quadrant abdominal pain. Patient Data Age: From the case: Displaced cholecystectomy clips.
Loading Stack - 0 images remaining. Status post cholecystectomy with surgical clips in gallbladder fossa. Displaced surgical clip in the right abdomen laterally to ascending colon. Case Discussion Surgical clips are applied during cholecystectomy on the cystic duct and artery.
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